ParkinsonCanadaV1, Main, Exploration, bibRecord, 001275

Challenges in diagnosis of young onset Parkinson's disease.

Identifieur interne : 001275 ( Main/Exploration ); précédent : 001274; suivant : 001276

Challenges in diagnosis of young onset Parkinson's disease.

Auteurs : Abdul Qayyum Rana [Canada] ; Ishraq Siddiqui ; Muhammad Saad Yousuf

Source :

Journal of the neurological sciences [ 1878-5883 ] ; 2012.

RBID : pubmed:22989613

English descriptors

KwdEn :
- Adult, Age of Onset, Delayed Diagnosis, Diagnosis, Differential, Early Diagnosis, Female, Humans, Male, Middle Aged, Office Visits (statistics & numerical data), Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (epidemiology), Parkinson Disease (psychology), Referral and Consultation (statistics & numerical data), Retrospective Studies, Symptom Assessment, Tremor (etiology), Young Adult.
MESH :
- complications : Parkinson Disease.
- diagnosis : Parkinson Disease.
- epidemiology : Parkinson Disease.
- etiology : Tremor.
- psychology : Parkinson Disease.
- statistics & numerical data : Office Visits, Referral and Consultation.
- Adult, Age of Onset, Delayed Diagnosis, Diagnosis, Differential, Early Diagnosis, Female, Humans, Male, Middle Aged, Retrospective Studies, Symptom Assessment, Young Adult.

Abstract

Young onset Parkinson's disease patients, typically aged 21 to between 40 and 55, have symptomatology similar to regular onset patients. Despite this, we suspect that physicians take longer to diagnose young onset patients since Parkinson's disease is ruled out due to the younger age. The history prior to diagnosis of 14 young onset patients (within 21 to 45 years of age) was compared with an equivalent number of regular onset patients matched by gender, tremor presence, and Hoehn and Yahr stage. Indeed, a longer period of time was taken to diagnose younger patients with an average of additional 15 months (p<0.001). This trend of older patients being diagnosed sooner was present in the regular onset group analyzed in isolation, but not so for the younger group. The lack of age-dependent variation in time required for diagnosis suggests that Parkinson's disease is not considered at all in the diagnosis for an extended period, accounting for the large difference in prevalence of young onset group to the regular onset group. We also observed a significantly higher number of neurologist visits (p=0.002) and clinical investigations (p<0.001) prior to diagnosis of young-onset patients. Due to the impact of delayed diagnoses on young onset patients and clinical resources, we propose that Parkinson's disease be more actively considered in differential diagnoses of younger patients presenting associated symptoms.

DOI: 10.1016/j.jns.2012.08.029
PubMed: 22989613

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">Young onset Parkinson's disease patients, typically aged 21 to between 40 and 55, have symptomatology similar to regular onset patients. Despite this, we suspect that physicians take longer to diagnose young onset patients since Parkinson's disease is ruled out due to the younger age. The history prior to diagnosis of 14 young onset patients (within 21 to 45 years of age) was compared with an equivalent number of regular onset patients matched by gender, tremor presence, and Hoehn and Yahr stage. Indeed, a longer period of time was taken to diagnose younger patients with an average of additional 15 months (p<0.001). This trend of older patients being diagnosed sooner was present in the regular onset group analyzed in isolation, but not so for the younger group. The lack of age-dependent variation in time required for diagnosis suggests that Parkinson's disease is not considered at all in the diagnosis for an extended period, accounting for the large difference in prevalence of young onset group to the regular onset group. We also observed a significantly higher number of neurologist visits (p=0.002) and clinical investigations (p<0.001) prior to diagnosis of young-onset patients. Due to the impact of delayed diagnoses on young onset patients and clinical resources, we propose that Parkinson's disease be more actively considered in differential diagnoses of younger patients presenting associated symptoms.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Challenges in diagnosis of young onset Parkinson's disease.

Challenges in diagnosis of young onset Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.